Major alterations included rebuilding the bridge, updating the main battery fire control to more modern standards and adding it for the secondary armament for the first time, and replacing her steam turbine engines.
Other major alterations included the onset of sexual development and the boost of secondary metabolism.
Major alterations included a radical change to overall treatment because of changes in diagnosis, disease stage or patient circumstance.
Major renal alterations include monolateral renal agenesis, monolateral or bilateral hypodisplasia and hydronephosis caused by ureteropelvic obstruction or vesicoureteral reflux [ 2].
For those families, major alterations could include transforming a family room into a wheelchair-accessible space, designed with wide doorways, and creating a fully equipped bathroom complete with grab bars.
Major human activities which lead to hydrologic alterations include irrigation (from ground water mining and surface water diversion), deforestation, wetland filling or drainage, and new dam construction.
Undifferentiated cells exhibited major apoptosis-associated alterations, including chromatin condensation and nuclear fragmentation, DNA fragmentation, exposure of phosphatidylserine on the outer leaflet of the plasma membrane (detected with annexin V-APC conjugates), as well as membrane permeabilization, as indicated by the staining with the vital dye PI.
The alterations include changes in manufacturing and design efforts, and, of course, job cuts.
Other UV-induced alterations include reduction in leaf area, alterations in plant architecture, and DNA damage.
RUNX1 alterations include RUNX1 mutations and breaks.
