"Obviously, this is the first quote-unquote major adversity that we have faced," Cavaliers Coach Mike Brown said.
Although she has a friendly, upbeat disposition — unlike some of the harder-edged women's stars over the years — she had to overcome major adversity to become a major champion.
Because the Warriors were so dominant during the regular season this year, it remained an open question about how Kerr, whose first year as a head coach ended with a championship, would handle things if his team encountered major adversity.
For anyone who knows me, and I mean really, truly knows me, I have beaten major adversity before, time and time again, with a positive attitude.
Similarly, a review (31) of adult retrospective reports of adverse childhood experiences indicated that reporting bias does not invalidate case-control retrospective studies of readily defined major adversity.
More recently resilience has come to the fore as a construct relevant to understanding the basis for health services continuing in contexts of major adversity, most notably in the context of health systems in West Africa and management of the Ebola virus outbreak [ 7, 8].
Oxytocin administration reduced cortisol levels in adults who had not experienced any major childhood adversity, but not in adults who endured parental separation early in life (Meinlschmidt & Heim, 2007).
Childhood adversity is a major cause of other diseases: people with four or more such experiences are twice as likely to suffer cancer and heart disease, partly as a result of substance abuse.
The major pathway through which environmental adversity leads to gene-linked changes in neurotransmitter function, brain structure and thence depression, is the HPA axis.
