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These results suggest that the identified compounds are the major active principles responsible for the estrogenic and AhR agonistic activities of the crude methanol extract of the aerial parts of Eriosema laurentii.
The method should be suitable for determining these major active principles in rhubarb crude drugs.
The major active principles quantified in this product were salidroside (8.4 mg/g) and p-tyrosol (1.9 mg/g) as described in previous reports [ 21, 22].
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All parts of the plant contain the major active principle gelsemine as well as other toxic strychnine-related alkaloids, such as gelseminine and sempervirine [ 1- 3].
Glyphosate, isoproturon, fluroxypyr, pirimicarb, imidacloprid, acetamiprid, tebuconazole, epoxiconazole, and prochloraz constitute, respectively, the active principles of 3 major herbicides, 3 insecticides, and 3 fungicides.
A major contribution to the discovery of new active principles comes from the exploitation of biological information.
Flavonoids, a major group of polyphenols, are considered to be the active principles in diverse medicinal plants and have been reported to possess numerous pharmacological properties.
This includes testing of all major antimalarials currently used on the market, a wide selection of active principles from the WHO list of essential drugs as well as a wide range of excipients used in the pharmaceutical formulation of tablets.
In this regard, it is noteworthy that the far greater toxicity of fullagricultural formulations compared to declared supposed active principles alone hasrecently been demonstrated also for six other major pesticides tested in vitro[22].
The observed pharmacological activities might have been attributed to the presence of active principles.
Triangles denote major active volcanoes.
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