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The methanolic extract was subjected to preliminary phytochemical test for the detection of major active moiety.
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Chemical reaction and in vivo metabolism studies of the four most potent 6S derivatives showed that both α,β-unsaturated carbonyl entity and catechol moiety act as major active groups for conjugation with the sulfhydryl groups of the cysteine residues.
For instance N-desmethylclozapine, the major clozapine metabolite, accounts for 50% of the active moiety and has partial agonism at different receptors, such as 5-HT1A (maximum effect (Emax) 69%; EC50 = 501 nmol/l), and M1 mAChR (Emax 67%; EC50 = 42 nmol/l).
We implemented the active moiety of antipsychotics, taking into account the activity of metabolites.
They possess an electrochemically or chemically active moiety.
Triangles denote major active volcanoes.
The prodrug is designed to overcome the solubility-limited bioavailability of the active moiety, BMS-626529.
One type of FR contains bromine atoms as the active moiety.
Tedizolid phosphate is a next-generation oxazolidinone prodrug that is transformed into the active moiety tedizolid.
Major active faults are drawn as red lines.
Purple broken lines are major active faults (HERP 2017).
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