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Studies by Mach-Aigner et al. have indicated that posttranslational modification of XYR1 constitutes a major activating aspect of its activation [ 5], whereas other studies suggested that a strongly elevated transcription level of xyr1 is important for hyperproduction of cellulases under inducing conditions [ 6, 7].
Indeed, TLR ligands provide a major activating signal to macrophages [42] and (myo)fibroblasts [9], [41], [43] via TLRs which on their turn can produce cytokines among which TGF-β.
In our study, the absence of the major activating dopaminergic receptors subtype D1 therefore question the so far considered predominant role of D1 receptor in locomotion and pain control.
The major activating site of PDE3B protein was the proximal tubule.
Recent reports have argued that gene expression is temporally structured in multiple waves in which key transcription factors play a major activating role [ 39].
mTORC1 complex is considered to be the major activating input that regulates cellular growth through downstream effectors S6K1 and 4EBP1 (eukaryotic initiation factor 4E binding protein 1) [ 23].
Among the major activating receptors are the NK group 2 member D receptor (NKG2D) [ 10- 12], the natural cytotoxicity receptors (NCR) [ 13- 15] and DNAM-1 [ 16].
Inactivating mutation of PTEN and activating mutation of PIK3CA have been detected in many human cancers and have been known as major activating mechanisms of AKT-signalling pathway in cancers (Testa and Bellacosa, 2001; Samuels et al, 2004).
The locus coeruleus may therefore provide a major activating signal to astrocytes during wake in the cortex, while the cholinergic system may have a prominent role in the hippocampus [ 73].
Two major activating phosphorylations of CHK1, on serine 317 and serine 345 (p-Ser317-CHK1 p-Ser345-CHK1 p-Ser345-CHK1 p-Ser345-CHK1respectivelylls expressing high levels of Aurora-A (Fig 5C).
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