Sentence examples for major abnormality of from inspiring English sources

The reported reasons for previous ML failure were as follows: restricted mouth aperture of below 25 mm, major abnormality of anterior neck structure, severe cervical spine ankylosis, previous causes combined with post-surgery/radiation sequels or unknown non-tumoral causes.

Therefore, enhanced de novo lipogenesis is regarded to be a major abnormality of hepatic lipid metabolism in subjects with NAFLD.

Congenital anomaly included any major abnormality of the central nervous, craniofacial, cardiovascular, digestive, urogenital, musculoskeletal, respiratory systems, or chromosome.

No major abnormality of mitochondrial DNA copy number was detected in muscle DNA from any of the patients with compound heterozygous SPG7 mutations (Table 1).

The molecular mechanisms leading to hepatic steatosis (fatty liver) in NAFLD are complex, but recent animal models have revealed that enhanced lipogenesis (fat formation) is a major abnormality of hepatic fatty acid metabolism that is associated with obesogenic diets.

Some of the promising research areas include cell-based therapy with mesenchymal stem cells, which could reverse the major abnormalities of lung injury [102], statin therapy [103], anti-inflammatory drugs, such as aspirin [104], or the modulation of signaling pathway of proteins involved in the regulation of vascular permeability [105, 106].

Congenital cataracts are common major abnormalities of the eye, which frequently cause blindness in infants [ 24].

Mouse knockouts of all three α-neurexin genes do not demonstrate major abnormalities of axonal pathfinding during development [Dudanova et al., 2007], although synaptic function is severely impaired.

Some of the promising research areas include cell-based therapy with mesenchymal stem cells, which could reverse the major abnormalities of lung injury [ 102], statin therapy [ 103], anti-inflammatory drugs, such as aspirin [ 104], or the modulation of signaling pathway of proteins involved in the regulation of vascular permeability [ 105, 106].

This discrepancy between results obtained ex vivo and in vivo suggest that despite providing what are generally accepted to be physiological levels of workload, nutrients and calcium supply, the ex vivo perfusion environment unmasked major abnormalities of mdx cardiac function and energy metabolism thereby exacerbating the observed changes.

Two major abnormalities of B cells in lupus are defective central checkpoints with a resultant partially autoreactive pre-immune repertoire, on the one hand, and enhanced T cell-dependent B-cell activation in the periphery with autoimmunity arising from somatic hypermutation and selected by apoptotic material displayed on FDC on the other.