Sentence examples for major βAR subtype from inspiring English sources

Echocardiography revealed that the B1KO mice display significantly decreased ejection fraction compared to control wild type (WT) mice, both under normal conditions (sham groups) and at 4 weeks post-MI, as expected since the β1AR is the major βAR subtype in the heart stimulating contractility (Table  1) [ 8].

The present study reports for the first time, to our knowledge, that cardiac GRK2 is an endogenous "stumbling block" that normally prevents β2AR signaling from stimulating contractility, mainly because it promotes association of this βAR subtype with PDE4D in the heart, a major molecular "brake" on cardiac β2AR-dependent contractility [ 6, 7, 15].

By contrast, agonist-promoted dissociation of PDE from the β1AR underlies the more "diffuse" and more powerful at stimulating contraction signaling of this βAR subtype [ 6, 7].

The βAR subtype was determined by competition-binding studies with the β1-selective adrenergic antagonist CGP20712A and the β2-selective adrenergic antagonist ICI118551.

To confirm the βAR subtype that mediates this effect, MDA-MB-231 cells were treated with selective antagonists and the effect on invadopodia was evaluated.

Importantly, upon stimulation with the adenylyl cyclase activator, Forskolin, all PDE4D isoforms show the same increase in activity in both cell types, suggesting that loss of one βAR subtype or the other has not perturbed overall cAMP signaling.

For instance in the city of Sao Paulo, the major subtypes are subtype B (79%–88%) and subtype F (4%–11%) [4], [5].

Hepatocellualr carcinoma (HCC) represents a major histological subtype of liver cancers.

In DLBCL studies, there are two major tasks: subtype classification and survival prediction.

To determine the risk of congestive heart failure (CHF) or cardiomyopathy in each major EB subtype.

Among primary liver cancers, hepatocellular carcinoma (HCC) is the major histological subtype.