Exact(8)
This is crucial because design is never done in isolation: designers create blueprints for artefacts that other people manufacture, sell and perform maintenance upon, and that aim to enhance the well-being of the most important "other" of all, the prospective user.
In conclusion, we have demonstrated for the first time an up-regulation of DNA DSBs repair activity during a differentiation process, that clearly underline the need for some tissues to ensure long-life maintenance upon stress conditions.
More remarkably, HIF-1α is also involved in regulating LICs maintenance upon ATRA treatment.
Through these findings we propose a cellular mechanism whereby SCs contribute to the regeneration of NMJs and skeletal muscle maintenance upon neuromuscular disruption.
Efficiency of the bioconversion processes is temperature-dependent owing to the strict dependence of enzymatic activity and cellular maintenance upon temperature.
2) In Figure 3, the authors showed that thymic but not peripheral naive T cells have defects in the maintenance upon adoptive transfer.
The current work examines the mechanism by which the promoter mutations act using a two-step CRISPR knockin approach in human ES cells and then studying the effect of the mutations on telomerase and telomere length maintenance upon differentiation.
The requirement of the EGFR pathway for enterocyte shape appears to occur during the maturation of newly synthesized enterocytes and affects at least three different morphogenetic events in the gut: the initial development of the adult gut, the basal maintenance upon aging and the accelerated renewal that occurs in response to damage induced by infection.
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