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In the landmark TAXIT trial, stable patients under infliximab maintenance therapy (approximately 80%% were in complete clinical remission according to clinical scores) were first dose-optimized to achieve infliximab serum concentration between 3 to 7mcg/ml and then randomly allocated to continued conventional care or to therapeutic drug monitoring (TDM) -based dose-optimization strategy [ 38].
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A loading dose was infused at zero and 2 weeks, and then maintenance therapy was administered at intervals of approximately 1 month.
Many questions about maintenance therapy remain unanswered, e.g., what kind of patients can achieve the best benefits from maintenance therapy?
Treatment consists of up to 4 cycles of induction therapy followed by maintenance therapy until disease progression or treatment discontinuation in approximately 900 patients (450 per treatment arm).
Previous studies of this nature have also reported considerable patient morbidity, but in those studies approximately three-quarters of patients were not receiving regular maintenance therapy and not all had a physician-confirmed diagnosis of asthma.
Approximately 20% of primary PTA recipients received sirolimus (SRL -based maintenance therapy (Table 3).
Approximately half (49%) of all enrolled patients were on maintenance therapy (i.e., successfully titrated to receive a stable pirfenidone dose) at time of reporting, with smaller proportions of patients titrating treatment (9%) or temporarily not receiving treatment (5%), as shown in Fig. 1.
The low prevalence of peri-implantitis in this study (approximately 10%) may be related to the fact that all the subjects received maintenance therapy [26].
At the end of 2013, 15,542 people were receiving methadone maintenance therapy (MMT) at 80 clinics [ 2], and in 2013, needle and syringe programmes (NSPs) distributed approximately 26.7 million needles and syringes or 98 syringes per PWID per year [ 2].
Approximately 50%% of these deaths in CR were probably therapy-related after induction, consolidation, and during maintenance therapy, and 50%% died for other reasons during long-term follow-up (Table 4).
Charlie's ABA therapy approximately cost $85 an hour.
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