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Because the ABM provides an intrinsic regulation of proliferation and stem cell maintenance, the stem cell feedback is replaced by this internal regulation.
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Self-renewal and limited proliferation are the processes that allow the maintenance of the stem cell pools throughout life [1].
The balance between maintenance of the stem cell state and terminal differentiation is influenced by the cellular environment.
Furthermore, it remains unknown whether additional novel stem cell factors are involved in the establishment and maintenance of the stem cell state.
Adult stem cells are characterized by the dual function to differentiate into different cell lineages and to self-renew for maintenance of the stem cell pool.
Therefore it is predicted that alterations in the balance of PcG members would have profound implications for maintenance of the stem cell state.
PPy(DBS) was best suited for NSC culture and supported long term maintenance of the stem cell state as well as differentiation along neural lineages.
Skin differentiation is a lifelong process that leads to the expansion of cells with specific, exquisite features from a relatively few progenitors that guarantee the maintenance of the stem cells pool.
This fact is due to the maintenance of the stem cell population near its carrying capacity, which prevents resistant cell populations from arising since we consider density-dependent growth dynamics.
Increasing studies support the notion that HIFs play an important role in the maintenance of the stem cell pool.
Regardless of stem cell type, current focus remains on stem cell expansion, maintenance of the stem cell state, differentiation, and, ultimately, transplantation and clinical application.
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