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This is consistent with the results reported in another intervention maintenance study of a telephone-based program in the primary care setting [ 37].
In a 24-week maintenance study of olanzapine LAI, apparent dose-associated changes were observed for both safety and efficacy parameters [ 2].
In a recently published 24-week maintenance study of olanzapine long-acting injection (LAI) in schizophrenia (Kane et al., 2010), apparent dose-associated changes were noted in both efficacy and safety parameters.
These analyses further investigated apparent dose-associated changes for both safety and efficacy variables observed in a 24-week maintenance study of olanzapine LAI in patients with schizophrenia [ 2].
This article reports the results of post hoc analyses of a 24-week maintenance study of olanzapine LAI [ 2] examining the potential association between olanzapine LAI dose and several safety and efficacy parameters of clinical interest.
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Therapies expected to improve functional abdominal symptoms might use this module as the primary endpoint, while maintenance studies of anti-inflammatory studies might use a co-primary endpoint of an objective marker of inflammation and the Bowel Signs and Symptoms and Abdominal Symptoms scales to demonstrate a long-term significant impact on multiple symptom domains important to patients.
The adverse event profile in this patient population was qualitatively similar to findings in acute and maintenance studies of quetiapine monotherapy in patients with bipolar I or II disorder (Bowden et al. 2005; McIntyre et al. 2005; Weisler et al. 2011).
In the maintenance study, the safety of long-term pemetrexed exposure was evaluated in patients who received 10 or more cycles of maintenance pemetrexed (N = 98) following induction therapy with a non-pemetrexed-containing regimen.
At entry to the maintenance study, the majority of patients in both groups had a normal mucosal appearance (sigmoidoscopy score of 0), with the remainder having a sigmoidoscopy score of 1.
Male and female patients were entered into this maintenance study following the induction of remission after an acute flare of mild to moderate UC.
The study population comprised patients who had experienced a disease flare-up immediately prior to entering the maintenance study (ie, were part of the active disease parent studies).
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