We also show that Wnt4, Jnk2 and Fz6 are all involved in BM LSK maintenance at steady state.
The cytotoxycity data also support the metabolism observation and show that the UMP/CMP kinase might not be critical for the maintenance of steady state levels of dFdC, L-OddC and 5-FU in cells.
We also demonstrate that Jnk activity and the presence of the receptor Fz6 were necessary for Wnt4-mediated LSK expansion, and that Wnt4, Jnk2 and Fz6 were all involved in BM LSK maintenance at steady state.
MIF plays important role in maintenance of steady state Cyclin D1 expression and cell proliferation in immortalized rodent fibroblasts through a number of signaling elements, including ERK activation [23].
10.7554/eLife.01684.004 Figure 2. Ais24 is required for the integrity of the MICOS complex and for maintenance of steady state levels of MICOS subunits, but Aim24-3xHA is not functional.
The phage-driven establishment and maintenance at steady state of high bacterial diversity recapitulates kill-the-winner ecological dynamics [ 20, 21], supporting arguments that such dynamics can arise by coevolution [ 13].
According to quadratic stability theory [ 19, 20], if the perturbative network described in (10) is robustly stable, the following inequality has a positive definite solution P=PT>0: (11) [ A 1 + η ] T P A 1 + η ≤ P Since robustness is the intrinsic perturbation tolerance ability with respect to the maintenance of steady state, the system must be stable and (11) should be satisfied.
Thus, p53-miRs acting on p53 downstream targets could significantly shorten the response delay, leading to more effective noise buffering, as well as precise definition and maintenance of steady states.
This behavour is called 'homeorhesis' the maintenance of a dynamic trajectory in analogy to the more static concept of homeostasis the maintenance of a (steady) state of the system [ 3].
This suggests that maintenance of the steady state localization of EGFP-LC3 does not require active export from the nucleus.
