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Unfortunately, the common response to a severe economic downturn is to defer capital projects and maintenance, resulting in a construction bust.
Specifically, S&P cites Bally's "substantial" capital expenditures for new club openings, acquisitions and maintenance, resulting in "fairly large free-cash-flow deficits," although it notes that the deficit has narrowed.
Some drainage channels are consequently inaccessible for maintenance, resulting in intermittent flooding; this is particularly severe in areas bordering Hungary.
This theory rests on the idea that organisms subjected to high levels of extrinsic mortality should be selected to invest less in somatic maintenance, resulting in shorter intrinsic lifespan [18].
In fact, errors may occur during the DNA methylation maintenance, resulting in genes or genomic regions that undergo hypomethylation or hypermethylation during aging [ 16, 148].
However, most patients with dyskeratosis congenita have a defect in the DKC1 gene that affects telomere maintenance, resulting in abnormally short telomeres.
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Stafford wished to retain the troops, but popular opposition to the financial burden of their maintenance resulted in the fall of his ministry.
Surface area-adjusted dosing (70 mg/m loading followed by 50 mg/m maintenance) resulted in drug exposures more comparable with adults [112,113].
For patients receiving R-CHOP induction, rituximab maintenance resulted in a median PFS from second randomization 51.8 months vs 23.0 months in the observation arm (HR, 0.54; P = 0.004).
Treatment with 80 mg per day prednisone with tapering dose and adalimumab, induction and maintenance, resulted in rapid resolution of the orbital myositis and ocular symptoms with no recurrences on follow-up at 10 months.
There is exquisite control over EC specification and arterial, venous, and lymphatic development, with key roles for Notch, COUP-TFII and PROX; dysregulation of any of these genes, and other genes involved in vascular development and maintenance, results in vascular pathology as demonstrated in both animal models and humans.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com