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Participants receive regular emails over the first 6 months with a tapered dose during the second 6 months (maintenance phase) to alert them to new content on the website.
The main outcome measures were percentages of urine specimens negative for heroin, cocaine, and both simultaneously; these were monitored during a 5-week baseline of standard treatment (to determine study eligibility), a 12-week intervention, and a 10-week maintenance phase (to examine intervention effects in return-to-baseline conditions).
This is followed by a prolonged maintenance phase to prevent disease flares.
The study comprised two parts: (i) a dose-finding phase to determine the individual maximum tolerated dose (MTD) for each patient; and (ii) a treatment maintenance phase to determine the response to seocalcitol and the tolerability of treatment.
At 6 months, patients with A1C ≤7.0% were monitored for up to an additional 24 months (maintenance phase) to evaluate how long the A1C goal (A1C ≤7.0% or A1C >7.0% but increased <0.4% from last A1C ≤7.0%) could be maintained (Fig. 1).
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To be eligible for analysis patients needed to have completed the acute phase of the study and be able to participate in the maintenance phase and to have no missing CGI-BP mania or depression ratings at baseline.
A third of patients had an inpatient admission in the initiation phase and although in some cases this may be accounted for by diagnosis of AF during an admission for a different primary reason, one in six (18%) patients were admitted to hospital for AF during the maintenance phase, similar to the EPHA registry (18.4% hospitalised in the previous year).
Most patients experienced improvements in seizure frequency, duration, and intensity during the Maintenance Phase (62 to 72%) and the Optimization Phase (65 to 74%).
Observations took place within the normal pattern of care on six occasions within the Acute Phase (baseline to 12 weeks) and four further occasions in the Maintenance Phase (up to 24 months).
One of the important activities of the maintenance phase is to understand the source-code first, and then change it.
Localization of PAR-6 and PAR-2 during maintenance phase appeared to be normal (Fig. 4Q and 5G), suggesting that the defects in centrosome orientation and posterior spindle placement are not responsible for the defect in polarity maintenance.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com