In order to minimise drug resistance, induction-maintenance (IM) therapy strategies begin with a period of intensified antiretroviral therapy (induction phase), followed by a simplified, long-term regimen (maintenance phase) [ 16- 19].
To present the treatment patterns, disease activity, and visual outcomes of eyes in the maintenance phase of a treat-and-extend regimen for neovascular age-related macular degeneration (nAMD).
Patients with A1C ≤7.0% continued into a 24-month maintenance phase evaluating how long each insulin regimen could maintain the A1C goal, which was the primary objective of the DURAbility of Basal versus Lispro mix 75/25 insulin Efficacy (DURABLE) trial.
In the 'Wait and Extend' regimen [ 34], after an initial loading dose, a flexible treatment regimen is applied during the maintenance phase depending on disease progression.
Studies had to have a flexible dosing regimen (at least during the maintenance phase); studies with specific criteria for dose escalation or dose escalation to a maximum dose were eligible.
A study of continuation design by Tohen et al. [ 32] comparing the efficacy between olanzapine and divalproex, although it kept the original regimen into and through the maintenance phase, the study design restricted the administration of sedatives for agitation, which may lead to more residual symptoms in the participants in the remission state.
15 A total of 21 male subjects attended up to three sessions: session 1 was a single constant-rate i.v. infusion over 1 hour to confirm the safety of a single dose of CPHPC over a wide dose range (5 70 mg), sessions 2 and 3 investigated i.v. infusion regimens over 24 hours (induction phase followed by maintenance phase), with total dose ranging from 86 960 mg.
The ongoing, 2-year maintenance phase will evaluate the length of time each starter insulin regimen is able to maintain A1C goals (i.e., regimen durability).
Durability of regimens will be evaluated in the following 2-year maintenance phase.
Steady-state trough serum concentrations of belatacept in the maintenance phase (during 5-mg/kg dosing) were similar between the HD and LD regimens.
