Sentence examples for maintenance of transformation from inspiring English sources

However, FGFR2 signaling in the tumor setting, where FGF2 and FGF7 are likely available from the surrounding microenvironment [30], [32], may establish a paracrine pathway leading to continued cancer cell survival, growth and maintenance of transformation in the presence of EGFR targeted therapies.

Thereby, TAX provides stimulatory signals resulting from the binding of ligands to their receptors and promotes cell proliferation as well as the initiation and maintenance of transformation (Grassmann et al, 2005; Sun and Yamaoka, 2005).

While PIK3CA activation may not be able to initiate OSE transformation, we conclude that activation of PIK3CA may be an important molecular event contributing to the maintenance of OSE transformation initiated by oncogenes such as K-ras.

The maintenance of the transformation zone on the ectocervix for a prolonged time increases its susceptibility to the external agents involved in dysplastic lesions (Autier et al, 1996).

The HPV E7 oncoprotein is expressed in cervical cancer and has been associated with the cellular transformation and maintenance of the transformed phenotype.

There was a very dominant CD8+ T-cell response to peptides covering HPV16 E6, a protein known to be critical for malignant transformation and maintenance of the transformed phenotype.

Although the catalytic activity of DOT1L has been shown to be required for leukemic transformation and maintenance of the transformed state by MLL and CALM fusion proteins in in vitro models, it is possible that DOT1L collaborates with other euchromatic modifiers such as Gcn5 to establish and maintain the altered gene expression levels in human leukemias.

These experiments demonstrate an essential role of MEK/ERK signaling for the maintenance of Raf induced transformation in vivo.

This integration enables the expression of viral proteins such as E6 and E7 which are key players in HPV-induced carcinogenesis as well as in the maintenance of the cell transformation phenotype [ 11, 12].

Standard methods for the growth, maintenance, and transformation of yeast and bacteria and for the manipulation of DNA were used throughout.

A. tumefaciens AGL-1 strain (Lazo et al. 1991) was used for plasmid maintenance and transformation of V. longisporum.