Sentence examples for maintenance of the stem from inspiring English sources
The balance between maintenance of the stem cell state and terminal differentiation is influenced by the cellular environment.
Self-renewal and limited proliferation are the processes that allow the maintenance of the stem cell pools throughout life [1].
Therefore it is predicted that alterations in the balance of PcG members would have profound implications for maintenance of the stem cell state.
PPy(DBS) was best suited for NSC culture and supported long term maintenance of the stem cell state as well as differentiation along neural lineages.
Furthermore, it remains unknown whether additional novel stem cell factors are involved in the establishment and maintenance of the stem cell state.
Adult stem cells are characterized by the dual function to differentiate into different cell lineages and to self-renew for maintenance of the stem cell pool.
Next, phosphorylated SOX2 is recruited and required for HHAT expression and therefore maintenance of the stem-cell phenotype.
In the current study, we assessed the role of SOX2 in the maintenance of the stem-like phenotype in the cells of HNSCC.
The microenvironment regulates the maintenance of the stem-cell pool and commitment towards specific lineages through intrinsic and extrinsic factors, creating niches.
Curcumin alone and in combination with chemotherapy was observed to inhibit spheroid formation and downregulate stem cell associated markers CD44 and CD166 and ALDH activity, in addition to downregulation of epidermal growth factor, insulin-like growth factor and Notch, all of which may have involvement in maintenance of the stem-like phenotype.
Our data partly confirm a recent study reporting the mRNA expression of CCN1, CCN2, CCN5 and CCN6 in MSCs, with a decrease in CCN1 and CCN6 expression during the chondrogenic differentiation of MSCs, suggesting that these proteins might be important regulators in the maintenance of the stem-cell phenotype [ 24].
