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Electrical remodeling, in contrast, is reversed by a few weeks of maintenance of sinus rhythm under experimental conditions.
In persistent AF, twice-daily dofetilide has been shown to be as or more effective than low-dose sotalol given twice daily for the maintenance of sinus rhythm in patients with AF.
Until recently, contemporary drug treatment of atrial fibrillation (AF) focused primarily on restoration and maintenance of sinus rhythm, predicated on the belief that if AF is abolished then problems associated with AF would be abolished too.
Conceptually, maintenance of sinus rhythm could prevent adverse outcomes related to AF. Rhythm control therapy has been only moderately effective in published trials, and its potential benefit was offset by side effects of repeated interventions.
This study was designed to compare two treatment strategies in patients with atrial fibrillation (AF): rhythm-control (restoration and maintenance of sinus rhythm) and rate-control (pharmacologic or invasive rate-control and anticoagulation).
Therefore, maintenance of sinus rhythm is an important clinical goal, especially when the patient is symptomatic, despite the fact that current treatment strategies are not sufficient to completely prevent recurrent AF.
Similar(14)
This disappointing outcome may relate to the low long-term maintenance rate of sinus rhythm in the rhythm control groups of these studies, being 63% after 5 years in the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) trial and 39% after 2.3 years of follow-up in the Rate Control versus Electrical Cardioversion (RACE) trial.
To compare the efficacy and safety of amiodarone and propafenone when used for the prevention of atrial fibrillation (AF) and maintenance of normal sinus rhythm in patients with refractory AF.
B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity.
These findings underscore the ability of IKs to contribute to rate-related adaptation of cardiac repolarization and maintenance of normal sinus rhythm and excitability during stress.
Clinical studies indicate that this period of time is crucial for the atrial reverse remodeling process that determines the probability of sinus rhythm maintenance [2, 40 42].
More suggestions(15)
maintenance of user
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