Sentence examples for maintenance of progenitor from inspiring English sources

One body of evidence demonstrates a role for Notch in the maintenance of progenitor cells and block of terminal differentiation of myeloid cells.

Hence, the relationship of Prdm16 to Notch signalling and a conserved role for Prdm16 in the maintenance of progenitor cell fate are very interesting prospects for further investigation in haemopoiesis and leukaemogenesis, as well as neurogenesis.

There is also down-regulation of genes that are associated with the maintenance of progenitor cell function, including Igdcc3 (Punc), Sall4, a subset of polycomb genes, and certain DNA and chromatin modifying components.

Our findings from organ cultures of developing prostates are consistent with the role of Wnt signaling in maintenance of progenitor cells in other tissues such as the intestine [33], mammary gland [34] and hematopoietic system [35].

Thus, long-term maintenance of progenitor cell compartment did not depend on IGF signaling.

Thus, Notch regulates the balance between neuronal differentiation and maintenance of progenitor cell fates, including of radial glia.

19 However, their specific target genes appear to be different since Hes1 maintains the progenitors and inhibits both neuronal and glial differentiation, whereas Hes5 cooperatively regulates maintenance of progenitors but promotes the glial cell fate.

Outside of the nervous system, the Notch pathway contributes to the maintenance of other progenitor and stem cell populations, such as Leydig progenitor cells of the testis and melanocyte stem cells (Moriyama et al., 2006; Tang et al., 2008).

The Wnt/β-catenin pathway plays a critical role in embryonic development, maintenance of multipotent progenitor cell populations and proliferation of many tissue types [1], [2].

Specifically, presenilins are required for maintenance of neural progenitor population as well as neurogenesis and neuronal migration [4], [5], [6], [7], [8].

Similarly, regulation of Notch signaling is essential for neurogenesis with activated Notch signaling being required for the maintenance of a progenitor fate in aspects of the CNS, including the VZ of the forebrain [13], [14], [19].