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Several growth factors have been shown to be relevant for stimulation of proliferation and maintenance of primitive function under in vitro conditions [5] [8].
Co-culture experiments with MSC demonstrated that cell-cell contact with stromal cells greatly enhances proliferation and maintenance of primitive markers.
Proliferation, maintenance of primitive immunophenotype and CFU frequency were significantly enhanced by addition of serum samples taken during hematopoietic stress after HSCT.
Therefore, we have taken serum samples from patients in the course of autologous HSCT to evaluate their effect on proliferation and maintenance of primitive function of hematopoietic progenitor cells.
We described for the first time the isolation and characterization of UC-WJ cells in a serum-free condition and maintenance of primitive mesenchymal phenotype.
Along the same lines, in vivo studies using THOC5 knockout mice show that THOC5 is required for the maintenance of primitive cells, and the cell proliferation/differentiation.
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Expansion of HSC requires both: proliferation to increase cell numbers and maintenance of their primitive phenotype and function.
In the embryonic AGM, therefore, BMP4 may have a similar effect on cell behaviour to that of TGF β on postnatal cells in the maintenance of a primitive, multipotent population that resides within the CD34+/c-Kitlow compartment.
Loss-of-function studies reveal an essential role for p27kip1 in the maintenance of the primitive state and self-renewal potential of LRCs, and thereby adult SC pool size during tissue turnover.
We conclude that typical testis architecture results from the maintenance and elaboration of primitive sex cords in T. scripta rather than the assembly of de novo structures as in mouse.
Our previous studies on STAT5 downregulation also showed impaired maintenance and expansion of primitive human hematopoietic stem and progenitor cells [9], [10].
More suggestions(14)
maintenance of primordial
maintenance of primary
maintenance of initial
maintenance of crude
maintenance of strong
maintenance of two-parent
maintenance of old
maintenance of didactic
maintenance of ultrasound
maintenance of historical
maintenance of new
maintenance of epithelial
maintenance of genomic
maintenance of healthy
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