Sentence examples for maintenance of matrix from inspiring English sources

When similar mutations are introduced into a murine model, mice develop a generally fibrotic phenotype indicating that selective collagen turnover is necessary for proper maintenance of matrix [42].

This allows the long-term culture of cartilage tissue over several weeks under maintenance of matrix integrity and homoeostasis.

p38 MAPK inhibition can partially reverse IL-1 inhibition of proteoglycan synthesis, and thus could contribute to maintenance of matrix proteins in cytokine-activated and stressed cartilage.

Many genes involved in the production and maintenance of matrix materials or extracellular polymeric substances (EPSs) have also been identified [ 5, 27– 29].

The supply of glucose for anaerobic metabolism is essential to the survival and proliferation of chondrocytes and for the maintenance of matrix integrity.

SPOCK2, also known as Sparc/osteonectin, was implicated, in a recent study, as a discriminator between SpA and healthy controls [ 22] and has been hypothesised to play roles in the regulation and production, assembly, or maintenance of matrix turnover in cartilage [ 36, 37].

Protease and endopeptidase inhibitor activities were also overrepresented for normal cartilage; these categories contain matrix metalloproteinase inhibitors essential to the maintenance of cartilage matrix (Table 2).

While explants diced into small pieces accentuate cell apoptosis and matrix degradation, the large explants used here minimize cell death and enable maintenance of normal matrix metabolism; thus, native collagen architecture is retained away from the cut edges of the disks.

Maintenance of cartilage matrix requires synchronization of a number of cellular functions, including coordinated protein secretion, cell-matrix signaling and protein degradation.

Insulin-like growth hormone (IGF-1) is considered to be the most important skeletal growth factor and it stimulates synthesis of collagen type I, increases matrix apposition rates and inhibits collagen degradation, effects that are important for bone synthesis and maintenance of bone matrix [ 20].

Taken together, type IX collagen is crucial for the maintenance of cartilage matrix and formation of collagen meshwork.