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MLL-FPs are thought to promote leukemogenesis through the epigenetic activation and maintenance of master regulatory factors such as HOXA9 and MEIS1, which set up gene expression networks responsible for constitutive activation of cellular growth and proliferation pathways.
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For this reason, WHO is currently advocating for the creation and maintenance of national-level master facility lists to enable informed health systems planning and management (World Health Organization 2012).
Each participating country will have a study monitor who will be responsible for overview and monitoring of trial activities at each study site within each country, including maintenance of the trial master file, site pharmacy files and site investigator file.
Microarray analyses detected a suite of master developmental regulators that control differentiation and maintenance of diverse cell lineages.
The results indicate that CK1δ plays a more prominent role than CK1ε in the maintenance of 24-hour rhythms in the master circadian oscillator.
The breeding, care, and maintenance of medieval war-horses, and the mastering of the skills of mounted combat, required immense amounts of time, skill, and resources.
Because sustainability can encompass so many different aspects in the design, master planning, operations, and maintenance of an airport, airport managers can experience difficulty in analyzing how to plan for sustainability most effectively.
For instance, ECAT4 was identified to be Nanog, a master regulator for the maintenance of mESC and hESC [3], [9].
However, with the increasing size of the data, the block location table and its corresponding maintenance could occupy more than half of the memory space and 30% of processing capacity in master node, which severely limit the scalability and performance of master node.
So local officials turned the maintenance of the temple over to the current masters of monastery marketing and kung-fu: the Shaolin monks.
In particular, NANOG is considered as a master transcription factor for the maintenance of the undifferentiated state and cellular self-renewal.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com