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The complement system, a well-characterised arm of the innate immune system, significantly influences the adaptive immune response via direct cell cell interaction and maintenance of lymphoid organ architecture.
The lymphotoxin-beta receptor (LTβR) pathway is important in the development and maintenance of lymphoid structures.
Lymphotoxin and TNF expressed by B cells are required for the maintenance of lymphoid follicles in Peyers patches of adult mice [ 26, 27].
Lymphotoxin signaling is important for the development and maintenance of lymphoid tissue structure, including Peyer's patches in the mucosa [ 33], and is also associated with the ability of mucosal DCs to regulate IgA production by plasma cells [ 34].
NF-κB transcription factors are essential for innate and adaptive immunity, cell survival, cellular stress responses, development and maintenance of lymphoid organ structures, and other biological functions [ 1- 3].
LTα has specific roles in the development and function of the immune system, mainly in lymphoid organ development, organization and maintenance of lymphoid microenvironments, host defense, and inflammation [ 18].
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Once BCR-ABL expression has been established, JAK2 is required only for lymphoid cell transformation, not for the maintenance of the lymphoid or myeloid leukemia.
Kuprash, D. V. et al. TNF and lymphotoxin β cooperate in the maintenance of secondary lymphoid tissue microarchitecture but not in the development of lymph nodes.
We also observed the local production of homeostatic chemokines that play a pivotal role in the architectural maintenance of tertiary lymphoid structures (CXCL13 and CCL21) inside BALT structures.
The formation and maintenance of several lymphoid structures in CXCL13-transgenic pancreata is known to be LTα and LTβR dependent, including HEVs, BP-3+, and CCL21+ stromal cells.
Strikingly, components of all known lysine acetyltransferase (KAT) complexes were down-regulated, as were genes required for growth and maintenance of the lymphoid phenotype.
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