Collectively, these data demonstrated that Gpr43−/− CBir1 Th1 cells induce more severe colitis, indicating that the SCFA-GPR43 interaction in effector T-cells protects the intestines from inflammation and contributes to the maintenance of intestinal homeostasis.
Highlighted Article: We show that GPA33, an intestine-specific cell surface protein, plays a role in the maintenance of intestinal barrier function and the prevention of intestinal pathologies such as food hypersensitivity, inflammatory bowel disease and colitis-associated cancer.
CDX2 is an intestine-specific homeobox transcription factor whose function ensures the development and maintenance of intestinal differentiation in the gut and ectopic sites, which was well established in animal models [ 8, 9].
Epithelial Sel1L is required for the maintenance of intestinal homeostasis.
Fevr, T., Robine, S., Louvard, D. & Huelsken, J. Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells.
Several functions have been attributed to these peptides in the "architecture" maintenance of intestinal villi acting over sub-epithelial fibroblasts.
The wide-ranging collection of such inducing genes suggests to the functions of Cdx2 in cell fate decision and maintenance of intestinal epithelia.
IL-17-expressing CD4 T helper (Th17) cells are important members of the intestinal immune cell community that contribute to protection against bacterial and fungal infections, and maintenance of intestinal homeostasis.
Activation of these intracellular receptors results in potent intestinal immune modulation including regulation and maintenance of intestinal intraepithelial lymphocytes and innate lymphoid cells, induction of the key barrier cytokine interleukin-22 and manipulation of the intestinal microbiota.
Normal glutamate metabolism has been found to be important for the maintenance of intestinal function.
Our work also reveals the importance of E-cadherin for the maintenance of intestinal epithelial homeostasis.
