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Tissue formation and longitudinal maintenance of hepatic phenotype are additionally independent of hepatocyte donor, age, or genetic background.
These results indicate that the actions of endothelin-1 on stellate cells may be an important physiological mechanism in maintenance of hepatic architecture.
Recent studies using conditional knockout mice indicate that Notch1 as well as Notch2 plays an important role postnatally in liver development and in maintenance of hepatic function.
These results and others highlight the role of PC synthesis in the maintenance of hepatic lipid metabolism.
Both, uptake and synthesis of cholesterol [ 16- 20] as well as maintenance of hepatic function [ 21] are essentially influenced by the action of microRNAs (miRNAs).
We also provide several lines of evidence that a key feature of the GhrR KO mouse is maintenance of hepatic insulin sensitivity during metabolic challenge.
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Likewise, additional molecular switches have been observed already and might regulate redistribution of some metabolic functions throughout the hepatic lobule (e.g., gluconeogenesis, fatty acid oxidation, glutamine synthetase) or deal with the protein responsible for the maintenance of the hepatic zonation (e.g., β-catenin, E-/N-cadherins) upon liver injury and repair.
It has been shown that dynamic three-dimensional perfusion culture is superior to other culture systems for inducing maturation of ESCs into fetal hepatocytes and prolonging the maintenance of the hepatic functions of those cells.
FXR appears to be necessary for preventing fasting hypoglycemia through maintenance of postprandial hepatic glucose production and glycogen storage (35).
The observed redistribution of hepato-splanchnic macrocirculatory blood flow can most probably be explained by the maintenance of the hepatic arterial buffer response.
In mammals, miRNA-122 has been shown to be implicated in the differentiation and maintenance of the hepatic phenotype [ 5- 8], and the regulation of metabolic liver functions, especially lipid metabolism.
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CEO of Professional Science Editing for Scientists @ prosciediting.com