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As such, it plays an important role in the cessation of dopaminergic neurotransmission and in the maintenance of extracellular dopamine homeostasis.
The contraction of connective tissue cells may facilitate their production and maintenance of extracellular matrix architecture and can benefit healing through wound closure.
They perform many functions, including biochemical support of the endothelial cells that form the blood-brain barrier, provision of nutrients to nervous tissue, and maintenance of extracellular ion balance.
Their functions have been considered to be logistic support for neurons, such as mediating energy metabolism for neurons or maintenance of extracellular medium concentrations [1], [2].
In neural tissues, such as the retina, the maintenance of extracellular potassium ion homeostasis is a crucial function of glia cells [3].
Importantly, the altered mammary gland development observed in both young and aged VDR KO mice occurred in the absence of hypocalcemia, indicating that these effects of VDR ablation are not secondary to the role of VDR in maintenance of extracellular calcium homeostasis.
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Both types of mucins play important roles in the regulation of cellular functions such as formation of physical barrier, maintenance homeostasis of extracellular environment, and regulation of cell growth and differentiation.
As the only cell type of the articular cartilage, chondrocytes are responsible for the synthesis and maintenance of the extracellular matrix and can react to mechanical forces and structural changes in the extracellular matrix [ 23].
Because articular chondrocytes are solely responsible for the production and maintenance of the extracellular matrix, chondrocyte depletion is implicated in cartilage degeneration, which pertains to OA pathogenesis [3], [4].
Astrocytes play many essential roles in the healthy central nervous system (CNS), including regulation of blood flow, provision of energy metabolites to neurons, participation in synaptic function and plasticity, and maintenance of the extracellular balance of ions, fluids and transmitters [2], [3].
Implantation of viable chondrocytes can assure prolonged maintenance of the extracellular matrix and integrity of the articular cartilage after transplantation.
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