For illustration, BioRAM is applied to four relatively common therapy‐driven drug delivery scenarios: rapid therapeutic onset, multiphasic delivery, delayed therapeutic onset, and maintenance of target exposure.
Men with osteoporosis should be given advice on lifestyle measures to decrease bone loss, including a balanced diet rich in calcium, weight bearing exercise, cessation of smoking, moderation of alcohol intake and maintenance of regular exposure to sunlight in summer months.
High drug dosing may seem desirable to sensitize basal ganglia circuits and promote TD induction (Additional file 2), but this often triggers acute dystonic reactions even during maintenance of drug exposure [ 80].
Appropriate antibiotic therapy in patients with severe sepsis and septic shock should mean prompt achievement and maintenance of optimal exposure at the infection site with broad-spectrum antimicrobial agents administered in a timely manner.
6 Golimumab concentrations reached steady state at wk12, with median trough serum golimumab concentrations of 0.27, 0.21 and 0.30 μg/mL at wk12, wk20 and wk52, respectively, suggesting maintenance of drug exposure up to wk52 with q8w administration of golimumab 2 mg/kg.
These data together suggest that aak-2, aakb-1, aakb-2 and aakg-2 have a role in maintenance of tissue during anoxia exposure.
These findings are consistent with the current paradigm in which efficacy of airway conidial clearance, and the nature of local inflammatory responses tailor induction and maintenance of specific immunity, not exposure to specific Aspergillus allergens.
In recent years, many additional components of ER stress resolution have been identified, often with roles in maintenance of metabolic homeostasis following exposure to stress.
Conversely, p32 siRNA treatment resulted in a significant effect on maintenance of XTT activity following exposure to arsenite at 150 or 300 μM, but not 500 μM arsenite.
It was thus possible to quantitate any interaction between cisatracurium and nitrous oxide during maintenance of anesthesia with longer exposure to nitrous oxide and with minimal disturbance of the clinical routine.
