They are critical for development and maintenance of epithelial architecture.
They are crucial factors for the development and maintenance of epithelial architecture.
In the kidney, primary cilia sense urine flow and are essential for the maintenance of epithelial architecture.
These cells contribute in a major fashion to gastrointestinal innate immune functions such as the production of antimicrobial peptides and mucus and maintenance of epithelial integrity.
Additionally, vitamin D has been shown to be important for the maintenance of epithelial and mucosal cells, in particular preserving the barrier functions of these cells [52].
The absence of FOXC2 (S I = 2∗105 molecules) results in low levels of ZEB1 mRNA and consequently the maintenance of epithelial phenotype (Fig. 6b, bottom panel) irrespective of the high levels of SNAIL (Additional file 1: Figure S10).
However, studies have also implicated HIF-independent NF-kB-mediated pathways in the host response at sites of inflammation, where NF-kB is required for the maintenance of epithelial barrier integrity [8, 21].
Cell migration represents a fundamental mechanism involved in the maintenance of epithelial homeostasis in the intestine.
This study is the first to demonstrate the essential nature of any domain within Bves for maintenance of epithelial phenotype and function.
TGF-β has been postulated to play an important role in the maintenance of epithelial homeostasis and the development of epithelium-derived cancers.
The C. elegans coiled-coil protein AJM-1 localizes to apical junctions and is required for embryonic elongation and maintenance of epithelial integrity [41], [42].
