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Alcohol dependence is characterized by an obsessive need for alcohol intake that is related to a subjective experience of craving that motivates to use alcohol and plays a significant role in maintenance of dependent behavior [1] [3].
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Unexpectedly, morc-1 is dispensable for siRNA inheritance but is required for target silencing and maintenance of siRNA-dependent chromatin organization.
Accordingly, GnIH inhibits the development and maintenance of gonadotropin-dependent gonadal functions [16].
Folate is an essential B vitamin required for the maintenance of AdoMet-dependent methylation.
Therefore, they are supportive for a role of HES1 in the maintenance of Notch3-dependent pro-tumour effects in RMS.
The increase of proximal absorption in Akita/A1AR double mutant mice is for the most part due to the increase of SNGFR, reflecting the maintenance of load-dependent fluid reabsorption.
ATP7A and ATP7B contribute to the maintenance of copper-dependent enzyme activity by delivering copper to the lumen of the secretory pathway in the trans-Golgi network, where copper metalation generates active cuproenzymes.
They showed that Myc inhibition triggers rapid regression of incipient and established lung tumors, defining an unexpected role for endogenous Myc function in the maintenance of Ras-dependent tumors in vivo.
Here, we establish that pharmacological inhibition of lysine deacetylases (KDACs) blocks the emergence and maintenance of Hsp90-dependent resistance to the most widely deployed antifungals, the azoles, in the human fungal pathogen Candida albicans and the model yeast Saccharomyces cerevisiae.
These are not recognized by available PI4P-specific PH domain reporters or current anti-PI4P antibody-staining protocols, but are nevertheless important in the maintenance of PI4K-dependent vesicular trafficking.
Redder colours denote higher recognition locus diversity, while the frequency of the cooperative allele is shown by contour lines; parameter spaces favouring the evolution and maintenance of cue-dependent cooperation thus have red colours and high values on the contour lines.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com