Sentence examples for maintenance of beta from inspiring English sources

FGF2 has been shown to be important in pancreatic development and maintenance of beta cell function, suggesting that FGF2 may promote pancreatic differentiation.

However, in addition to regulating beta cell mass (via apoptosis), the mitochondria are also critical for maintenance of beta cell function through the coupling of a glucose stimulus to insulin release [23] [25].

We can only speculate that catecholamines play a more central role in the triggering or maintenance of beta cell differentiation than of alpha-cell differentiation, or in the induction of distinct classes of NGN3+ progenitors that preferentially differentiate into insulin cells.

Chaturvedi, C.-P. et al. Dual role for the methyltransferase G9a in the maintenance of beta-globin gene transcription in adult erythroid cells.

In this context, miRNAs may play major roles in the maintenance of beta-cell phenotype, thus representing candidate regulators of dedifferentiated fate acquisition.

Upregulation of NKX2-2 is considered one of the primary regulatory events required for the maintenance of beta-cell identity [ 69].

Given recent studies reporting an association of common genetic variation within pre-miRNAs with type 2 diabetes susceptibility [ 26] and an enrichment of T2D GWAS signals in genes predicted to be targeted by islet-expressed miRNAs [ 27], the importance of miRNAs to maintenance of beta-cell function cannot be overstated.

Though several mechanisms have been implicated in adult beta cell maintenance and renewal [ 2], it has been demonstrated that the proliferation of differentiated beta cells is the major mechanism for the maintenance of adult beta cell mass [ 3].

FGF2 signaling has also been suggested to play an important role in development of the exocrine pancreas [41] and in maintenance of adult beta cell function [42].

Several transcription factors implicated in progenitor and endocrine specification also play key overlapping roles in the postnatal expansion, maturation and maintenance of adult beta cells.

Monitoring the transcriptome of functional and disturbed beta-cells might reveal genes and pathways involved in the maintenance of normal beta-cell functional capacity.