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These data establish a link between hormonal response, proliferation, modulation of MMP activity and maintenance of basement membrane integrity that depend on a balance in the expression levels of PR-A and PR-B isoforms.
Perlecan is a critical regulator of growth factor-mediated signaling and angiogenesis, and is fundamental for the maintenance of basement membrane homeostasis [ 59], suggesting that its alteration could play an important role in CRC progression.
Perlecan is a critical regulator of growth factor-mediated signaling and angiogenesis, and is fundamental for the maintenance of basement membrane homeostasis [ 30], and as such its alteration could play important roles in IDC progression.
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Special cells that may be concerned with the formation and maintenance of the basement membrane of the glomerular walls are called mesangial cells.
The intermittent approach led to maintenance of the basement membrane and collagen fibers (Fig. 3I).
TEM indicated that following decellularization there was complete removal of all cellular material and maintenance of the basement membrane (Fig. 8A).
In addition, MECs have natural tumor suppressor functions, including maintenance of the basement membrane, providing a physical barrier between epithelial cells and the surrounding stroma, and maintenance of epithelial cell polarity.
rs3767140 of HSPG2, which is involved in maintenance of glomerular basement membrane electrostatic charge, was also associated with diabetic nephropathy in the meta-analysis (OR 0.72 [95% CI 0.59 0.87]), and additionally with diabetic nephropathy in Europeans with type 1 diabetes mellitus (OR 0.64 [95% CI 0.49 0.84]).
Gandellini et al. (2012) [ 82] reported that miR-205 controls the deposition of laminin-332 and its receptor integrin-β4 as well as participates in a network involving ΔNp63α, which is essential for maintenance of the basement membrane in prostate epithelium.
Our most recent studies have shown DG is expressed in radial glia during neocortical histogenesis, and that glial DG is essential for multiple developmental processes, including maintenance of the basement membrane integrity, normal radial glia morphology, organization of neocortical proliferation, and cortical plate lamination [ 8].
The primary source of ECM in the liver is hepatic stellate cells (HSCs) [ 6] and following liver injury; HSCs undergo phenotypic changes from quiescent vitamin A storing cells, involved in maintenance of the normal basement matrix, into proliferative myofibroblast-like cells, expressing myogenic markers such as alpha smooth muscle actin (αSMA).
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