To study whether Cdc42 regulates the maintenance of apical structures of fully differentiated supporting cells, independently of its maturational role, mice were treated with tamoxifen between P16 and P18, and the analysis was performed at P25.
Rab protein is an important molecular switch in the cell, which controls the transport of vesicles in various ways, so as to promote the establishment and maintenance of apical polarity (Cole and Fowler 2006; Samaj et al. 2006).
Our analysis of pupal eyes suggests that Cnn is required for the maintenance of apical and AJ domains of photoreceptor cells, as Baz and apical markers fail to form correct localizations in cnn mutant clones.
Moreover, study reported that Rspo2 is required for the maintenance of apical ectoderm ridge in the hind limbs of the mice.
In previous studies, ArhGAP44 has been associated with the maintenance of apical microvilli in polarized epithelial cells as well as postsynaptic maturation and vesicle release (Rollason et al., 2009; Nahm et al., 2010; Raynaud et al., 2013, 2014).
Of the many extracellular signals that control the expansion and/or maintenance of apical progenitors, Notch signaling has been shown to be crucial for the maintenance of this population (Yoon and Gaiano 2005).
