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Gene-regulatory networks control the establishment and maintenance of alternative gene-expression states during development.
We investigated the tactic fitness structure for maintenance of alternative reproductive tactics in scarab dung beetles that constitute the first known examples of conditional male trimorphism.
Wilde's final play again returns to the theme of switched identities: the play's two protagonists engage in "bunburying" (the maintenance of alternative personas in the town and country) which allows them to escape Victorian social mores.
Our evolutionary model will however allow us to state the conditions for the maintenance of existing splicing variants in populations, and therefore the maintenance of alternative splicing per se.
Since several studies have shown that point mutations in splice sites, splicing enhancers or silencers, may generate splicing variants for single genes [25] [27], we developed a theoretical model of cis-regulated alternative splicing.This simple model allows us to predict the conditions for the emergence and maintenance of alternative splicing variants for genes expressed in several tissues.
While the width of expression is overall positively correlated with the number of alternative splicing events, this relationship does not seem to explain the lack of genes with alternative splicing variants on the Y chromosome, which is in keeping with a model where balancing selection contributes to the maintenance of alternative splicing.
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Substituting ERK kinase inhibition with inhibition of members of the SRC tyrosine kinase family can enable maintenance of an alternative ground state, alternative 2i, or a2i (Li et al., 2011; Shimizu et al., 2012).
The tRNAs of eukaryotes contain stretches of base sequences that are similar to those found in their respective rRNA, and these two RNAs share common ancestral origins rather than common functions [ 25]. snoRNA has diverse roles in RNA silencing, telomerase maintenance and regulation of alternative splicing.
It further predicts the conditions for the emergence and the maintenance of cis-regulated alternative splicing, which are both favored by the tissue specific expression of splicing variants.
This paper describes two probabilistic approaches for evaluating the economic impacts of alternative maintenance strategies, design strategies (design load), and compensation fees for undelivered energy.
This approach did not allow the country's management agencies to evaluate the cost effectiveness of alternative maintenance and repair strategies, which resulted in an inefficient use of funds.
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