The lysosome contributes to cellular maintenance through involvement in autophagy and to immunity through protease-mediated degradation of phagocytosed substances and apoptosis-like programmed cell death [ 55].
As astrocytes have an important role in the BBB maintenance, their involvement in molecular mechanisms underlying BBB disruption in ALS has been more thoroughly explored.
These suggested protein trafficking and lysosomal maintenance roles indicate involvement of CLN3 in cytoskeleton (cell morphology, migration) (27, 38, 39), synapse (37, 40) and neurotransmission (41, 42) functions.
Dicer has been shown to be essential in stem cell maintenance by its involvement in auto-renewal and proliferation (Jin and Xie, 2007).
NASA needs more hands-on involvement in maintenance and safety, the report said, and not just serve as a "safety auditor" of contractor activities.
Regulatory initiatives for biotechnology-derived animals and their products should be able to ensure high standards for human and animal health, a sound scientific basis for evaluation; transparency and public involvement, and maintenance of genetic diversity.
Building the plants is not enough: In the 1970s, Nepal's government built microhydro plants in rural areas, but within a few years many of them broke down because of a lack of community involvement and maintenance systems.
The system should also have low capital expenditures (capex; that is, low investment in central servers and data centers) and operating expenditures (opex; e.g., low involvement from maintenance personnel).
Moreover, the existence of different maintenance strategies and the involvement of a large number of decision-making factors have made the decision-making process a complex and challenging task.
However, in order to ultimately achieve the brain-like neural networks, the capability of using PCM-based device to imitate biological neuron with the involvement of maintenance of the equilibrium potential, the transient dynamics, and the neurotransmission process is highly preferred.
