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This higher maintenance requirement directly translates into a bigger maintenance gap.
Where does the maintenance gap in a particular species come from?
Hence, to understand the evolutionary cause of aging, research should focus on the maintenance gap as a whole.
What contributed most to the maintenance gap in a specific organism depends on the environmental niche an organism lives in, but both factors that contribute to the maintenance gap, maintenance requirement and maintenance effort, are complementary rather than mutually exclusive and are united in the concept of the maintenance gap.
Any factor that would increase the maintenance gap would directly increase the rate of aging, be it increasing maintenance requirement or decreasing maintenance effort.
Maintenance requirement may grow so high that a maintenance gap would remain even if all resources were to be allocated to maintenance, especially because age-independent mortality tends to obscure disadvantageous late-life consequences, as was suggested by Medawar (1952).
Similar(52)
Evidence is in favour of the view that both formation and maintenance of gap junctions is critically dependent on the presence of correct mechanical stabilization [36].
Collectively, we demonstrated that the absence of ST2-mediated signalling pathway in non-hematopoietic cells protects mice against DSS-mediated colitis with maintenance of gap junctions.
The cells were morphologically normal, as assessed by light and electron microscopy, with maintenance of gap junctions between cells and limited vacuolation.
Interestingly, Stat3 inhibition in two NSCLC lines which exhibit extensive junctional communication (QU-DB, SK-LuCi6) abolished GJIC, indicating that Stat3 does in fact play a positive role in the maintenance of gap junction function.
On the contrary, Stat3 inhibition in lines displaying extensive GJIC (QU-DB, SK-LuCi6) suppressed junctional permeability, indicating that Stat3 activity is actually required for the maintenance of gap junction function in these lung cancer lines.
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