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The importance of the maintenance function has increased because of its role in keeping and improving system availability and safety, as well as product quality.
However, the maintenance function has only been touched on.
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Recent advances in our understanding of the complex processes of Treg lineage differentiation, maintenance, and function has paved the way for developing strategies to manipulate these important cells for therapeutic benefit in many diseases.
A group of terpenoid compounds have been present since the evolution of the genus Eucalyptus ca. 50 million years ago and Keszei et al. [ 44] argued based on a phylogeny of TPS fragments from more than 20 species that early divergence and maintenance of function has suggested a closer correlation between sequence homology and function than seen in other plant groups.
In development, loss of REST function is an integral step in NSC differentiation, and inappropriate maintenance of REST function has been found to prevent differentiation of NSC into neurons [ 4- 6].
Rif1 is conserved upto mammals but its function has diversified from telomere length regulation to maintenance of genome integrity.
Proper proteosomal function has been shown to be essential for the maintenance of plant health and homeostasis [ 63].
It is possible that MMP3 has a maintenance function in cartilage that is lost in end-stage OA.
This suggests that EP3 likely has a maintenance function in the epidermis where it would respond primarily to COX-1 elicited PGE2 due to the lack of expression of COX-2 in naive skin.
In addition to the widely appreciated telomere maintenance function, new roles of telomerase have recently been suggested.
A limitation in our understanding of epithelial tissue and tumors that are derived from them is that most insight into the formation, maintenance, function and pathology of epithelial tissue has depended on the analysis of traditional 2D cell tissue culture.
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