One study reported that all patients had an AUC/MIC ≥ 400 for micro-organisms with an MIC ≤ 1 mg/L for weight-based maintenance dosing.
The patients experiencing SE were initially treated with boluses of valproic acid, levetiracetam, and clonazepam, followed by maintenance dosing.
Combined, these observations suggest that maintaining response and quality-of-life improvements could require continuous maintenance dosing.
On the additive scale, individuals who received bolus dosing had 59 more hospitalizations for major organ system infection, per 1000 person-years, than individuals who received maintenance dosing.
We developed 2 indicators to measure conformance and appropriateness of antipsychotic prescribing with treatment guidelines for patients with schizophrenia: (1) the antipsychotic monotherapy and (2) antipsychotic maintenance dosing.
Patients with a catheter who received bolus dosing experienced approximately 100 more events per 1000 person-years for these outcomes relative to patients with a catheter who received maintenance dosing.
The effect measures for the catheter subgroup (Table 3) were imprecise due to small sample size, but the magnitude of the rate differences suggests that this group, in particular, may be at greater risk of infection-related outcomes with bolus versus maintenance dosing.
In PRECiSE 4, patients who relapsed after week 2 in PRECiSE 1 (Fig. 4) or after randomization in PRECiSE 2 (Fig. 2), receive reinduction with CZP 400 mg (three doses at week 0, 2, and 4) followed by maintenance dosing every 4 weeks (Fig. 6).
The extent to which RCT data are representative of outcomes obtained in routine clinical practice may be particularly pertinent in the case of AI, given the complexity of the conventional dosing regimen, patient self-adjustment of the dose, compliance issues with prescribed treatment regimens and the difficulties associated with optimizing maintenance dosing [ 28].
Anemia (an expected on-target effect) was mitigated by the strategy of 5F9 prime and maintenance dosing.
At standard maintenance dosing of 5 mg/kg every 8 weeks, a trough >3 μg/ml was predicted to be achieved in 32% of patients.
