The next four samples were collected just before the next maintenance doses (i.e. at 6, 12, 18 and 24 h).
According to our respondents, the median acceptable maintenance dose of oral prednisone (i.e., corticosteroid-sparing) was 7.5 mg/day (range 0 to 10 mg/day), and the median acceptable dose of topical prednisolone acetate 1% was 2 drops/day (range 1 to 6 drops/day).
Active CMV infection was treated with GCV (5 mg/Kg twice daily, i.v) for seven days, followed by a maintenance dose of 5 mg/Kg/day, i.v., three times a week for four weeks, and CMV disease was treated with GCV (5 mg/Kg twice daily, i.v) for 21 days, followed by a maintenance dose of 5 mg/Kg/day, i.v., three times a week for four weeks.
To prevent adrenal crisis (AC) there are three areas to be considered: i) the daily maintenance dose, ii) the daily dose/exposure of cortisol required to mimic normal physiology and iii) the need for extra cortisol during an intercurrent illness or non-illness-related events, such as exercise, in order to prevent AC.
Specifically, rotigotine-treated patients who received a mean 2.1 mg/24 h maintenance dose had significantly reduced PLM during sleep (i.e., a reduction from 50.9 PLM/h at baseline to 8.1 PLM/h at end of maintenance).
The 8 mg/kg s.c. dose was expected to result in trastuzumab serum levels in the range of those achieved with the 6 mg/kg i.v. maintenance dose.
The three published dose algorithms can all be used for a priori dose predictions, i.e. to predict the maintenance dose based on baseline values of the covariates.
In the second step, the maintenance dose for each child was estimated as described under (i) and (ii) above, but now conditioned on the individual parameter estimates.
In a study of caffeine for AOP, a loading dose of 10 mg⁄kg caffeine (i.v. or orally) and a maintenance dose of 2.5 mg⁄kg once daily worked efficiently [ 76].
