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This became important in Ms Schiavo's case because of the reasonable issues surrounding care, continuation of care, interventions versus maintenance, and most vitally, decisions to end life.
Only acute treatments (no maintenance or continuation treatments) were included.
Maintenance or continuation of weight reductions calculated by (Δ 12months - baseline) – (Δ 6 months - baseline) defined as change in weight ≤0kg.
Maintenance or continuation of waist circumference reductions calculated by (Δ 12months – baseline) – (Δ 6 months - baseline) defined as change in waist circumference ≤0cm.
The interventions have to focus primarily on the treatment of depressive symptoms and need to be acute treatments (maintenance or continuation treatments will be excluded).
Two different approaches have been evaluated; the so-called continuation maintenance when the maintenance agent was part of initial therapy and is continued in the absence of disease progression ("maintained") or switch maintenance when a third agent is initiated after a defined number of cycles chemotherapy in the absence of disease progression.
Two monoclonal antibodies, cetuximab and bevacizumab, are used as continuation maintenance, but the incremental benefit of the maintenance therapy with these agents is undetermined.
Several phase III trials with both chemotherapeutic and targeted agents have demonstrated either PFS prolongation (continuation maintenance) or both PFS and OS benefit (switch maintenance).
"During this time, pemetrexed for continuation maintenance had been included in the CDF, threatened with delisting twice, only to be included again on appeal," he said.
The maintenance of blood continuation is the need of self-social integrity (Yan 2012).
Phase III trials have not revealed an overall survival benefit for continuation maintenance chemotherapy, and this approach should be considered investigational.
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CEO of Professional Science Editing for Scientists @ prosciediting.com