Proteins involved in redox maintenance clustered together (PARK7, PRDX2, PRDX3, PHB, GSTP1).
Industrial sectors characterized by indirect use of asbestos have also been found to contribute significantly to MM cases in several clusters, namely the non-asbestos textile industry (see Sarnico, Legnano, Cirié, Prato, Dalmine and Padua) [ 25, 35, 36], railway carriage construction and maintenance (clusters of Padua, Reggio nell'Emilia, Naples and Prato) [ 37- 39] and metal engineering (Legnano).
In addition to the already mentioned challenges and overheads related to the maintenance of clusters and their cluster-heads, it is clear that, even though routing overheads can be reduced, the cluster-head will always have to be part of any routing path, leading to non-optimal paths, and additional interferences in the vicinities of cluster-heads.
These results have shown that LIF and BMP signaling pathways are integrated into the ESC pluripotency maintenance TF cluster (OCT4, SOX2 and NANOG) through SMAD1 and STAT3; and multiple transcription factor clustering is the mechanism to recruit cell-specific enhancer targeting for lineage-specific transcription regulation.
In addition to muscle mass maintenance, a cluster of miRNA species (miR -23, -103, -107, -278 etc).
A benefit when using directory lookup sharding mechanisms is that EHRs can easily be moved between shards, for example when maintenance or cluster re-balancing is needed.
Conservation of gene coding sequences and clustering patterns indicated that maintenance of clusters may be essential for normal expression of genes or those sequences in transcribed regions have characteristics that efficiently suppress rearrangement.
Overheads can include node discovery, context aware functionalities (context gathering, maintenance and distribution), cluster functionalities (cluster formation, cluster maintenance, etc).
Simultaneously, the distinct genome clusters were independently homogenized, resulting in the maintenance of clusters of highly similar repeats through concerted evolution.
This "priming" through maintenance of clusters (or slow dissociated of channels from clusters) would therefore be dependent on magnitude and/or time of the first, or cluster-inducing stimulus.
