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Mechanism of murine epidermal maintenance: cell division and the voter model.
Klein, A. M., Doupé, D. P., Jones, P. H. & Simons, B. D. Mechanism of murine epidermal maintenance: Cell division and the voter model.
They are critical for many important cellular processes, such as cell growth, shape maintenance, cell division, motility and internal transport pathways (Pollard and Cooper, 2009; Shih and Rothfield, 2006; Cabeen and Jacobs-Wagner, 2005, 2010).
To achieve indeterminate growth, meristems must maintain a strict regulation of stem cell maintenance, cell division and cell differentiation.
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Sox2 may facilitate the maintenance of cell division in the embryo of Oct4 +ve cells, since embryos did not continue beyond the 30-cell stage when it was depleted.
The metabolic sensor AMPK appears essential for embryonic development, maintaining cell polarity and cell cycle progression [18], [33], [34], [35], [36], and the upstream kinase LKB1 is critical for cardiac development, and in hematopoietic stem cell maintenance and cell division [37], [38], [39], [40].
Thus, this ancestral PI3K isoform is critical for nutrient acquisition, energy maintenance and cell division.
Phosphorylation is probably the most studied protein post-translational modification in proteomics; it provides an important function in signal transduction, metabolic maintenance and cell division [ 53].
Understanding the role that the maintenance of cell division and differentiation of stem cells plays may lead to new insights into the signalling pathways involved in cancer progression and, ultimately, yield new approaches for cancer treatment.
In cervical cancer, expression profiling studies have helped to identify a number of potential diagnostic markers like mini chromosome maintenance 5 (Mcell, cell division cycle protein 6 (CDC6) and chromatin licensing and DNA replication factor 1 (CDT1) [ 12, 13].
Msi1 is associated with the maintenance and asymmetric cell division of neural and epithelial progenitor cells [ 19].
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