Sentence examples for maintenance and viability from inspiring English sources

In addition, it has been suggested that activation of the PI3K/Akt pathway is required for the maintenance and viability of cancer stem cells in breast cancer, prostate cancer, and brain tumor [11 13].

Similar to yeast Est1, Smg6 is reported to be involved in the regulation of telomere maintenance and viability of human cancer cells.

Membrane trafficking processes are vital for cellular maintenance and viability, hence inhibition of these events would significantly impact on cellular functions.

Autophagy, which is a bulk protein and organelle degradation process essential for cell maintenance and viability, can enhance the efficacy of BCG as a vaccine by increasing antigen presentation in mouse DCs (Jagannath et al, 2009).

The development of in vitro model of tamoxifen resistance provides a potentially useful tool for the identification of novel signalling mechanisms important for maintenance and viability of drug-resistant cancer progenitors.

The fact that CXCR4 is present in normal and cancer stem-like cells in various tissues suggests that this molecule could be essential for maintenance and viability of the tumour progenitor cell population.

Incidentally in these works, autophagy was elegantly shown to be critical for bioenergetics maintenance and cell viability in vitro, but also to play an essential part in vivo in the survival of the whole organism.

Similar to its mammalian orthologues, C. elegans AMPK is also activated by AMP and energy stresses (Apfeld et al., 2004; Schulz et al., 2007), and it plays an important role in starvation responses, including extension of lifespan by nutritional restriction and maintenance of viability and germline quiescence during dauer diapause (Narbonne and Roy, 2006; Greer et al., 2007; Schulz et al., 2007).

It is known that the PI3K/Akt signaling pathway is activated and plays a role in the maintenance of pluripotency and viability of stem cells [7].

Aberrant activation of the Ras/Raf-pathway contributes to essential aspects of tumor development and progression such as cell cycle deregulation, avoidance of apoptosis, cell motility and drug resistance and are moreover known to be important for tumor maintenance and cancer cell viability at late stages of tumorogenesis [ 19, 20].

These results suggest that gas1+ is essential for the maintenance of cellular integrity and viability during vegetative growth and also for cell morphogenesis.