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In adults, Hh signaling is curtailed and has limited functions such as stem cell maintenance and tissue repair.
SIRT3 is dispensable for HSC maintenance and tissue homeostasis at a young age under homeostatic conditions but is essential under stress or at an old age.
As VEGF is required for cell maintenance and tissue homeostasis, inhibiting endogenous VEGF signaling leads to additional side effects [ 55].
Despite these evidences that increases in Wnt signaling have adverse effects on stem cell maintenance and tissue aging, the mechanism is still poorly understood.
The most significantly downregulated network (with a score of 44 and 22 focus molecules) was that of cellular assembly and maintenance and tissue development (ESM Fig. 1c).
They are believed to be critical in cell development, proliferation, communication [ 8], metabolism [ 5], stem-cell maintenance, and tissue differentiation [ 9].
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These findings suggest clear therapeutic targets for boosting regenerative capacity, rejuvenating tissue maintenance and forestalling tissue aging.
Maintenance, regeneration, and tissue repair happen when there is adequate rest and sleep.
Furthermore, Notch signaling functions to regulate stem cell maintenance and adult tissue homeostasis (Liu et al. 2010).
Autophagy and apoptosis are well-characterized processes that contribute to the maintenance of cellular and tissue homeostasis.
miRNAs have been widely shown to modulate various critical biological processes, including differentiation, apoptosis, proliferation, the immune response, and the maintenance of cell and tissue identity1,2.
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maintenance and cell
management and tissue
maintenance and bone
housekeeping and tissue
maintenance and advertising
maintenance and improvement
maintenance and desilting
maintenance and packing
maintenance and capital
maintenance and restoration
maintenance and training
maintenance and mortgage
maintenance and renewal
maintenance and demolition
maintenance and safety
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