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Our straight-forward, ontomimetic approach, imitating the process of development, requires only a single cell-handling step, provides reproducible results for a range of tested geometries and size scales, and overcomes inherent limitations in cell maintenance and maturation, while achieving high yields of CMs with developmentally appropriate temporal changes in gene expression.
Different from the VEGF and FGF2 system, both of which promote sprouting angiogenesis, the angiopoietin system is a major regulator of vessel maintenance and maturation [ 37].
Thus, further studies are needed to investigate how persistent expression of conversion factors like Neurog3 affects maintenance and maturation of endocrine phenotypes in converted cells.
It was consistently demonstrated that astrocytes the most abundant population of glial cells, are essential for brain homeostasis and maintenance and maturation of the BBB [ 36– 36].
For examples, the BA/F3 cells, described to mature to Ig-producing cells in vivo, do not express Pax5, a factor shown to be indispensable for B-cell lineage maintenance and maturation.
The microenvironment that supports mammalian HSC generation in vivo contains a variety of factors that may work synergistically or antagonistically at different stages of HSC induction, maintenance and maturation.
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The unique microenvironment and interaction with the specific cell types is thought to be a key mechanism in regulating the maintenance of self-renewal and maturation capacities by stem cells.
It is known that GAK plays a crucial role in clathrin-mediated membrane trafficking and maintenance of centrosome maturation and mitotic chromosome assembly (Eisenberg and Greene, 2007; Sato et al., 2009; Shimizu et al., 2009).
Whatever the bacterial species involved and the complexity of the resulting community, biofilm formation is a dynamic process highly dependent on environmental signals, passing through a four-stage universal growth cycle consisting of initiation, maturation, maintenance, and dissolution phases, regardless of the phenotype of the constituent microorganisms [17].
Whatever the bacterial species involved and the complexity of the resulting community, biofilm formation is a dynamic process highly dependent on environmental signals, passing through a four-stage universal growth cycle consisting of initiation, maturation, maintenance, and dissolution phases, regardless of the phenotype of the constituent microorganisms [ 17].
In circulating blood, LPA modulates blood pressure [ 8, 9], maintenance of pregnancy [ 10] and maturation of embryonic vessel systems [ 11].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com