Such a study has recently been performed by deleting an essential genome-maintenance and checkpoint regulator, ATR, in adult mice (Ruzankina et al, 2007).
CAD25142.1 and CAD25955.1 are related to budding yeast Tel1p and are likely to be involved in telomere maintenance and the DNA damage checkpoint response as discussed above.
The kinase activity of BubR1 is stimulated by the microtubule motor protein, CENP-E, and is required for checkpoint maintenance and signalling in metazoans (Abrieu et al, 2000; Mao et al, 2003, 2005; Weaver et al, 2003).
Downregulation and functional attenuation of Survivin revealed severe defects in mitotic spindles assembly and maintenance, compromised spindle checkpoint surveillance, aberrant chromosome movements, increase in ploidy and the inability to complete cytokinesis.
A second article by Bin Wang [ 11] describes how BRCA1, an important tumor suppressor and a critical DNA damage response mediator, interacts with its partners to regulate activities of multiple repair and checkpoint pathways for genome maintenance.
Several miRNAs have also been implied in controlling the balance of stem cell maintenance and differentiation - a crucial checkpoint for sustaining adult neurogenesis throughout adulthood.
We conclude that S92 phosphorylation is important for stable Cdc20Slp1-APC/C interactions and in particular for maintenance of checkpoint arrest.
NHEJ, HR and checkpoint proteins all play roles in physiological telomere maintenance.
Two SL cancer-related partners of PRDX2, RAD50 and MRE11A are part of MRN protein-complex involved in DNA double-strand break repair, cell-cycle checkpoint activation, telomere maintenance and meiotic recombination [ 68].
In addition to its role in HR, Srs2 is also involved in other DNA metabolism processes, including post-replication repair (PRR), preservation of replication fork integrity, DNA-damage checkpoint responses, DNA triplet maintenance and non-homologous end joining (NHEJ).
