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There is currently a significant unmet medical need for an effective DME treatment that not only stabilizes but improves and maintains vision and has a better safety profile than the available DME treatment options.
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In 2011, the FDA approved Regeneron's Eylea (aflibercept), an antibody fragment that helps maintain vision in patients with wet age-related macular degeneration.
To protect their eyes, the falcons use their nictitating membranes (third eyelids) to spread tears and clear debris from their eyes while maintaining vision.
At week 52, all 70 patients treated with IVT-AFL maintained vision; 23 of 24 (96%) of patients in the Rq4 group maintained vision (data not shown).
The primary endpoint was the proportion of patients who maintained vision (lost <15 ETDRS letters).
It is noteworthy that this level of maintaining vision was also achieved for the subgroup of patients with VA ≥20/40.
In the anecortave acetate group, 73% of patients maintained vision compared with 47% in the sham group.
Apart from cataract surgery, treatments are available which at best maintain vision, or otherwise postpone visual acuity deterioration.
Intraocular injection with either bevacizumab or the variable fragment of a similar VEGF antibody, termed ranibizumab, can initially reverse the vision loss and then maintain vision.
For example, treating AMD at an earlier stage when lesions are smaller could mean that fewer injections may be needed to maintain vision.
At week 52, all Japanese patients in the IVT-AFL groups (n=70) maintained vision, compared with 96% of Japanese patients (n=23/24) treated with ranibizumab.
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CEO of Professional Science Editing for Scientists @ prosciediting.com