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Here, we show that an active response to hypoxia disrupts cellular proteostasis – the coordination of protein synthesis, quality control, and degradation that maintains the functionality of the proteome.
Whether these two events are mechanistically linked awaits further study, but the results clearly demonstrate that USP13 participates in ERAD by an indirect mechanism that maintains the functionality of Bag6.
The very flexibility that maintains the functionality of their enzymes at physiological temperatures renders these proteins both heat labile and cold labile (Makhatadze and Privalov, 1995; Privalov, 1990; D'Amico et al., 2003).
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This suggested that, despite the fact that the salmon elongases appear to be subjected to functional constraints in order to maintain the functionality of the protein, the nucleotide sequence of one of the duplicates seems to be diverging faster than the other.
Greider and Blackburn found that telomerase adds DNA to telomeres and thereby helps maintain the functionality of chromosomes.
These proteases are responsible to degrade key proteins that maintain the functionality of the BBB.
Vibration control is important in maintaining the functionality of the buildings surrounding a metro.
In this way, we maintain the functionality of signature that works as a proof of authorship in Android.
The PSS planning approach can maintain the functionality of products for customers throughout the whole product life-cycle.
The energy dissipation restrainer remains elastic and provides a reaction force to restrain the displacement of the girder during small earthquakes, maintaining the functionality of the bridges.
However, one of the most important aspects of these conformations is maintaining the functionality of the immobilized protein, which is determined by the choice of lipids and surfactants employed in the reconstitutions.
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