Sentence examples for maintains stem cells from inspiring English sources

Blood vessels also interact with neural stem cells in the developing and adult nervous system, providing a "vascular niche" that maintains stem cells, promotes their division, and expands neurogenesis [42].

LIF is a member of the IL-6 cytokine family that maintains stem cells in an undifferentiated state and promotes stem cell renewal [ 23].

Three transcription factors, Nanog, Oct4 and Sox2 form the core of a regulatory circuit, which maintains stem cells capacity for self-renewal and pluripotency.

Despite their high potential to proliferate, the niche maintains stem cells in a quiescent and low metabolic state to prevent stem cell exhaustion [22].

In normal tissue, it maintains stem cells in their undifferentiated state and controls differentiation (Wegner, 2005; Kelsh, 2006; Wong et al, 2006), whereas in MEL it serves as a marker of the stem-like CD271-positive cells (Civenni et al, 2011).

Rhee, H., Polak, L. & Fuchs, E. Lhx2 maintains stem cell character in hair follicles.

To test whether an active mechanism maintains stem cell pools in the Drosophila midgut, we performed partial ISC depletion.

Equivalent to the role of WUSCHEL (WUS) and WOX5 in the SAM and RAM24,25, respectively, WOX4 activity maintains stem cell fate23,26.

This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.

Importantly, our data suggests that Oct4 maintains stem cell identity by targeting key regulatory genes which play critical roles in determining cell fate.

Wnt signaling controls stem behaviors, maintains stem cell habitus, and regulates cell migration and differentiation [ 5- 7].