The emphasis throughout is on self-help and on productive work not entirely from financial considerations but because self-help maintains self-respect and affords an outlet for the creative drive, while productive work is more pleasurable for most people than enforced idleness.
The immune system maintains self-tolerance through the interplay of several mechanisms.
This is combined with a gradient-based optimization approach to compute three-dimensional, parameterized curves that minimize the sum of an elastic (bending) energy and a proximity energy that maintains self-avoidance by a penalization technique.
This TF maintains self-renewal and pluripotency, preventing differentiation in embryonic [69] and neuronal stem cells [70].
Expression of Stat3 maintains self-renewal in the absence of LIF [7], while disruption of Stat3 results in ES cell differentiation [5].
miR-21 is upregulated upon differentiation of the leukaemia cell line HL-60 [52]; furthermore, in ESCs, the transcription factor REST maintains self-renewal and pluripotency through suppression of miR-21 [53].
Furthermore, Sox2 in association with the POU domain transcription factor Oct4 and homeobox transcription factor Nanog form a regulatory core, which maintains self-renewal of the pluripotent ICM in the embryo and ES cells [4], [15], [20] [21], and is unique to mammals [22].
SOX2 maintains self-renewal of undifferentiated cells and is expressed in the otic proneural domain.
NANOG is a direct target of the LIF-STAT3 pathway, and it also maintains self-renewal of CSCs through the IGF1R signaling pathway [25].
WIC maintains self-reported data obtained at the first clinic visit for all women enrolled in the program at the end of each month.
Indeed, MEK inhibition on normal stem cells (induced pluripotent stem cells and embryonic stem cells) maintains self-replication of the pluripotent state and inhibits their commitment to differentiate.
