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In advanced CKD, FGF23 no longer maintains phosphate homeostasis and the suppression of 1,25(OH ₂D production exerted by FGF23 induces PTH elevation, resulting in secondary hyperparathyroidism (SHPT).
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OsNLA1 plays a key role in maintaining phosphate homeostasis in rice.
The coordination of three organs, including the intestine, kidney, and bone, is necessary to maintain phosphate homeostasis.
The critical role that phosphorus plays in cell physiology has resulted in development of elaborate mechanisms designed to maintain phosphate balance.
More than 90% of the filtered phosphate is then reabsorbed to maintain phosphate balance.
Furthermore, dietary phosphorus restriction may be associated with longer-term impracticalities and is often insufficient to maintain phosphate control [ 19].
Therefore, we consider it more likely that smoking reduces FGF23 sensitivity, thus necessitating an increased production to maintain phosphate excretion.
Studies have suggested that the type III sodium-dependent phosphate transporters, PiT1 and PiT2, are also involved in maintaining phosphate balance.
(c) Cartoon illustrating a hypothetical model in which a 10-bp burst enables a hexameric ring ATPase to maintain phosphate contacts on the same DNA strand.
The high level of FGF23 in CKD is considered to further increase as a compensatory response to maintain phosphate balance because of suppressed renal phosphate excretion or phosphate overload [ 30, 31].
Serum concentration of fibroblast growth factor 23 (FGF23) increases in parallel with parathyroid hormone (PTH) as renal function declines in chronic kidney disease (CKD) to maintain phosphate and calcium homeostasis [ 1, 2].
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